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Study design

study design

Enrollment and endpoints

1. Enrollment of patients

  1. 1) Inclusion criteria
    • - Patient suspected of glomerular disease who received kidney biopsy in participating university medical centers
    • - Children (age<18 years) also included
  2. 2) Exclusion criteria
    • - Patients who previously received a kidney transplant

2. Clinical endpoints of this study

  • 1) Deterioration of clinical outcomes
    • - Doubling of serum Cr
    • - Decrement in estimated glomerular filtration rate (eGFR) by more than 30%
    • - End-stage renal disease
    • - Cardiovascular events
    • - Death
  • 2) Improvement of clinical outcomes was defined by the remission of glomerulonephritis
    and proteinuria < 0.3 g/day

    * Patients who have proteinuria <0.3g/day at baseline have no improvement in clinical outcomes